Cross-chain arbitrage involves exploiting price differences of the same or related assets across different blockchain networks. It's a growing field within MEV as more chains and layer 2 solutions emerge. Traders, DeFi users, and cross-chain protocol developers commonly use this term. To excel in cross-chain arbitrage, one should understand multiple blockchain ecosystems, be proficient in cross-chain communication protocols, and have expertise in high-speed, cross-chain trading strategies.